Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

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第一作者： Jingyu,Zhang

第一单位： Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.

作者： Jingyu,Zhang ^[1] ; Jinxin,Che ^[1] ; Xiaomin,Luo ^[2] ; Mingfei,Wu ^[3] ; Weijuan,Kan ^[1] ; Yuheng,Jin ^[3] ; Hanlin,Wang ^[1] ; Ao,Pang ^[3] ; Cong,Li ^[4] ; Wenhai,Huang ^[1] ; Shenxin,Zeng ^[3] ; Weihao,Zhuang ^[5] ; Yizhe,Wu ^[5] ; Yongjin,Xu ^[1] ; Yubo,Zhou ^[1] ; Jia,Li ^[6] ; Xiaowu,Dong ^[2]

作者单位： Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China. ^[1] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. ^[2] National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. ^[3] School of Pharmacy, Fudan University, Shanghai 200032, China. ^[4] Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou 310058, P. R. China. ^[5] Department of Lymphoma, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou 310005, P. R. China. ^[6] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Tsuihang New District, Guangdong 528400, P. R. China. ^[7] Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou 310018, P. R. China. ^[8] Cancer Center, Zhejiang University, Hangzhou 310058, P. R. China. ^[9]

主题词人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);淋巴瘤(Lymphoma);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1021/acs.jmedchem.2c00324

PMID 35671249

发布时间 2022-07-26

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