换一批Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors.
第一作者：
Martin,Selinger
第一单位：
Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760, České Budějovice 370 05, Czech Republic.;Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, České Budějovice 370 05, Czech Republic.
作者：
关键词
A3SS, alternative 3′ splice siteA5SS, alternative 5′ splice siteACACA, Acetyl-CoA Carboxylase AlphaAKR1C2, Aldo-Keto Reductase Family 1 Member C2ANKS1A, Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1AANOS1, Anosmin 1AOX1, Aldehyde Oxidase 1APOBEC3G, Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3GAPOL1/6, Apolipoprotein L1/6ARID2, AT-Rich Interaction Domain 2AUTS2, Activator Of Transcription And Developmental Regulator AUTS2Alternative splicingAstrocytesBCL11B, BAF Chromatin Remodeling Complex Subunit BCL11BBCL9L, BCL9 Transcription Coactivator-likeBDKRB2, Bradykinin Receptor B2BDNF, Brain Derived Neurotrophic FactorBEND3, BEN Domain Containing 3BSA, bovine serum albuminBST2, Bone Marrow Stromal Cell Antigen 2CALB1, Calbindin 1CAMK2A, Calcium/Calmodulin Dependent Protein Kinase II AlphaCD, complement determinantCDKN1C, Cyclin Dependent Kinase Inhibitor 1CCFAP61, Cilia And Flagella Associated Protein 61CHRNA3, Cholinergic Receptor Nicotinic Alpha 3 SubunitCHRNB4, Cholinergic Receptor Nicotinic Beta 4 SubunitCLIC5, Chloride Intracellular Channel 5CMPK2, Cytidine/Uridine Monophosphate Kinase 2CNS, central nervous systemCNTN2, Contactin 2CREG2, Cellular Repressor Of E1A Stimulated Genes 2CXADR, Coxsackievirus B-Adenovirus ReceptorCYYR1, Cysteine And Tyrosine Rich 1DACH1, Dachshund Family Transcription Factor 1DAPI, diamidino-2-phenylindoleDCC, Netrin 1 ReceptorDCX, DoublecortinDDX60, DExD/H-Box Helicase 60DDX60L, DExD/H-Box 60 LikeDE, differentially expressedDENV, Dengue virusDIRAS2, DIRAS Family GTPase 2DLX1/5/6, Distal-Less Homeobox 1/5/6DNMT3B, DNA Methyltransferase 3 BetaDPYSL2, Dihydropyrimidinase Like 2EBF1, EBF Transcription Factor 1EGF, Epidermal Growth FactorELAVL2/4, ELAV Like RNA Binding Protein 2/4EPHB1, EPH Receptor B1EPSTI1, Epithelial Stromal Interaction 1ERBB4, Erb-B2 Receptor Tyrosine Kinase 4ES, exon skippingESRRG, Estrogen Related Receptor GammaFGFb, Fibroblast Growth Factor 2FPKM, Fragments Per Kilobase of transcript per Million mapped readsFUT9, Fucosyltransferase 9G2E3, G2/M?Phase Specific E3 Ubiquitin Protein LigaseGABRG2, Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma 2GAPDH, Glyceraldehyde-3-Phosphate DehydrogenaseGAS2L3, Growth Arrest Specific 2 Like 3GAS7, Growth Arrest Specific 7GATAD2B, GATA Zinc Finger Domain Containing 2BGFAP, Glial Fibrillary Acidic ProteinGIPC2, GIPC PDZ Domain Containing Family Member 2GLRA2, Glycine Receptor Alpha 2GNG2, G Protein Subunit Gamma 2GO, gene ontologyGOLGA4, Golgin A4GRIN2A, Glutamate Ionotropic Receptor NMDA Type Subunit 2AGSEA, gene set enrichment analysisHERC5/6, HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5/6HEYL, Hes Related Family BHLH Transcription Factor With YRPW Motif LikeHPRT1, Hypoxanthine Phosphoribosyltransferase 1HS, hot-spotHSPA6, Heat Shock Protein Family A (Hsp70) Member 6HUDD (ELAV4), Hu-Antigen D/ELAV Like Neuron-Specific RNA Binding Protein 4IFI6, Interferon Alpha Inducible Protein 6IFIH1 (MDA5), Interferon Induced With Helicase C Domain 1/Melanoma Differentiation-Associated Protein 5IFIT1-3, Interferon Induced Protein With Tetratricopeptide Repeats 1–3IFITM1/2, Interferon Induced Transmembrane Protein 1/2IFN, interferonIGB, Integrated Genome BrowserIL6, Interleukin 6IR, intron retentionISG20, Interferon Stimulated Exonuclease Gene 20ISGF3, Interferon-Stimulated Gene Factor 3 GammaISGs, interferon-stimulated genesJEV, Japanese encephalitis virusKCND2, Potassium Voltage-Gated Channel Subfamily D Member 2KCNK10, Potassium Two Pore Domain Channel Subfamily K Member 10KCNS2, Potassium Voltage-Gated Channel Modifier Subfamily S Member 2KIT, KIT Proto-Oncogene, Receptor Tyrosine KinaseKLHDC8A, Kelch Domain Containing 8AKLHL13, Kelch Like Family Member 13KRR1, KRR1 Small Subunit Processome Component HomologLCOR, Ligand Dependent Nuclear Receptor CorepressorLEKR1, Leucine, Glutamate And Lysine Rich 1LGI1, Leucine Rich Glioma Inactivated 1LRRTM3, Leucine Rich Repeat Transmembrane Neuronal 3LSV, local splicing variationLUZP2, Leucine Zipper Protein 2MAN1A1, Mannosidase Alpha Class 1A Member 1MAP2, Microtubule Associated Protein 2MBNL2, Muscleblind Like Splicing Regulator 2MCTP1, Multiple C2 And Transmembrane Domain Containing 1MMP13, Matrix Metallopeptidase 13MN1, MN1 Proto-Oncogene, Transcriptional RegulatorMOI, multiplicity of infectionMTUS2, Microtubule Associated Scaffold Protein 2MX2, MX Dynamin Like GTPase 2MYCN, MYCN Proto-Oncogene, BHLH Transcription FactorNAV1, Neuron Navigator 1NCAM1, Neural Cell Adhesion Molecule 1NDRG4, N-Myc Downstream-Regulated Gene 4 ProteinNEK7, NIMA Related Kinase 7NFASC, NeurofascinNKAIN1, Sodium/Potassium Transporting ATPase Interacting 1NMI, N-Myc And STAT Interactor 2NRAP, Nebulin Related Anchoring ProteinNRARP, NOTCH Regulated Ankyrin Repeat ProteinNREP, Neuronal Regeneration Related ProteinNRN1, Neuritin 1NS3, flaviviral non-structural protein 3NXPH2, Neurexophilin 2NYNRIN, NYN Domain And Retroviral Integrase ContainingNeuronsNeuropathogenesisOAS, 2′-5′-Oligoadenylate SynthetaseOASL, 2′-5′-Oligoadenylate Synthetase LikeONECUT2, ONECUT-2 Homeodomain Transcription FactorOPCML, Opioid Binding Protein/Cell Adhesion Molecule LikeOTX2, Orthodenticle Homeobox 2PBS, phosphate buffer salinePBX1, Pre-B-Cell Leukemia Transcription Factor 1PCDH18/20, Protocadherin 18/20PFKFB3, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3PIK3C2B, Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 BetaPIP4P2, Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2PLCH1, Phospholipase C Eta 1POU3F4, Brain-Specific Homeobox/POU Domain Protein 4PPM1L, Protein Phosphatase, Mg2+/Mn2+ Dependent 1LPPP1R17, Protein Phosphatase 1 Regulatory Subunit 17PRDM12, PR Domain Zinc Finger Protein 12PSI, percent selective indexPSRC1, Proline And Serine Rich Coiled-Coil 1PTPN5, Protein Tyrosine Phosphatase Non-Receptor Type 5PTPRH, Protein Tyrosine Phosphatase Receptor Type HRAPGEF5, Rap Guanine Nucleotide Exchange Factor 5RBFOX1, RNA Binding Fox-1 Homolog 1RIG-I (DDX58), Retinoic Acid-Inducible Gene 1 ProteinRNF212, Ring Finger Protein 212RNVU1, RNA, Variant U1 Small NuclearRSAD2, Radical S-Adenosyl Methionine Domain Containing 2RTL8B, Retrotransposon Gag Like 8BResponse to infectionSAMD9, Sterile Alpha Motif Domain Containing 9SEMA3E, Semaphorin 3ESH3TC2, SH3 Domain And Tetratricopeptide Repeats 2SHF, Src Homology 2 Domain Containing FSHISAL1, Shisa Like 1SIAH3, Siah E3 Ubiquitin Protein Ligase Family Member 3SIRPA, Signal Regulatory Protein AlphaSLITRK5, SLIT And NTRK Like Family Member 5SNP, single-nucleotide polymorphismSOGA1, Suppressor Of Glucose, Autophagy Associated 1SPSB4, SplA/Ryanodine Receptor Domain And SOCS Box Containing 4ST6GAL1, ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1TBC1D30, TBC1 Domain Family Member 30TBEV, Tick-borne encephalitis virusTFAP2A, Transcription Factor AP-2 AlphaTFAP2B, Transcription Factor AP-2 BetaTHSD7A, Thrombospondin Type 1 Domain Containing 7ATHUMPD2, THUMP Domain-Containing Protein 2/SAM-Dependent MethyltransferaseTIPARP, TCDD Inducible Poly(ADP-Ribose) PolymeraseTM4SF18, Transmembrane 4 L Six Family Member 18TMC8, Transmembrane Channel Like 6TMEM229B, Transmembrane Protein 229BTMTC1, Transmembrane O-Mannosyltransferase Targeting Cadherins 1TNFSF10, TNF Superfamily Member 10TRHDE, Thyrotropin Releasing Hormone Degrading EnzymeTRIM38, Tripartite Motif Containing 38TSHZ1, Teashirt Zinc Finger Homeobox 1Tick-borne encephalitis virusTranscriptomicsUSP18, Ubiquitin Specific Peptidase 18/ISG15-Specific-Processing ProteaseUTR, untranslated regionUTS2R, Urotensin 2 ReceptorWNV, West Nile virusXAF1, XIAP Associated Factor 1XRN1, 5′-3′ Exoribonuclease 1ZIKV, Zika virusZMAT3, Zinc Finger Matrin-Type 3ZMYM5, Zinc Finger MYM-Type Containing 5ZNF124, Zinc Finger Protein 124ZNF730, Zinc Finger Protein 730gRNA, genomic TBEV RNAhNSC, human neural stem cellslncRNA, long non-coding RNAmRNA, messenger RNAmiRNAmiRNA, micro RNAncRNA, non-coding RNApc-mRNA, protein-coding mRNAqRT-PCR, quantitative reverse transcription real-time PCRsnRNP, small nuclear ribonucleoproteinsvd-sRNA, virus-derived small RNA
DOI
10.1016/j.csbj.2022.05.052
PMID
35685361
发布时间
2022-07-16
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