Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

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第一作者： Joseph M,Replogle

作者： Joseph M,Replogle ; Reuben A,Saunders ; Angela N,Pogson ; Jeffrey A,Hussmann ; Alexander,Lenail ; Alina,Guna ; Lauren,Mascibroda ; Eric J,Wagner ; Karen,Adelman ; Gila,Lithwick-Yanai ; Nika,Iremadze ; Florian,Oberstrass ; Doron,Lipson ; Jessica L,Bonnar ; Marco,Jost ; Thomas M,Norman ; Jonathan S,Weissman

关键词 CRISPR Integrator complex Perturb-seq cell biology chromosomal instability genetic screens genotype-phenotype map mitochondrial genome stress response single-cell RNA sequencing

主题词染色体图(Chromosome Mapping);基因组学(Genomics);基因型(Genotype);表型(Phenotype);单细胞分析(Single-Cell Analysis)

DOI 10.1016/j.cell.2022.05.013

PMID 35688146

发布时间 2024-09-02

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