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Heterogeneity in statin responses explained by variation in the human gut microbiome.

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第一作者： Tomasz,Wilmanski

第一单位： Institute for Systems Biology, Seattle, WA 98109, USA.

作者： Tomasz,Wilmanski ^[1] ; Sergey A,Kornilov ^[1] ; Christian,Diener ^[1] ; Matthew P,Conomos ^[2] ; Jennifer C,Lovejoy ^[1] ; Paola,Sebastiani ^[3] ; Eric S,Orwoll ^[4] ; Leroy,Hood ^[1] ; Nathan D,Price ^[5] ; Noa,Rappaport ^[6] ; Andrew T,Magis ^[7] ; Sean M,Gibbons ^[8]

作者单位： Institute for Systems Biology, Seattle, WA 98109, USA. ^[1] University of Washington, Genetic Analysis Center, Seattle, WA 98195, USA. ^[2] Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA. ^[3] Oregon Health Sciences University, Portland, OR 97239, USA. ^[4] Institute for Systems Biology, Seattle, WA 98109, USA; Thorne HealthTech, New York, NY 10019, USA. ^[5] Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address: noa.rappaport@isbscience.org. ^[6] Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address: amagis@isbscience.org. ^[7] Institute for Systems Biology, Seattle, WA 98109, USA; University of Washington, Department of Bioengineering, Seattle, WA 98105, USA; University of Washington, eScience Institute, Seattle, WA 98195, USA. Electronic address: sgibbons@isbscience.org. ^[8]

关键词 Translation to patients cardiometabolic health microbiome personalized medicine pharmacogenomics pharmacomicrobiomics statins

医学主题词横断面研究(Cross-Sectional Studies);糖尿病, 2型(Diabetes Mellitus, Type 2);人类(Humans);羟甲基戊二酰基CoA还原酶抑制剂(Hydroxymethylglutaryl-CoA Reductase Inhibitors);RNA, 核糖体, 16S(RNA, Ribosomal, 16S)

DOI 10.1016/j.medj.2022.04.007

PMID 35690059

发布时间 2026-03-07

基金项目

U19 AG023122/AG/NIA NIH HHS/United States

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Med (New York, N.Y.)

2022年3卷6期

388-405.e6页

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Med (New York, N.Y.)

2022年3卷6期

388-405.e6页

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Heterogeneity in statin responses explained by variation in the human gut microbiome.

Med (New York, N.Y.)

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Heterogeneity in statin responses explained by variation in the human gut microbiome.

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