Association of Predicted HLA T-Cell Epitope Targets and T-Cell-Mediated Rejection After Kidney Transplantation.

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作者： Aleksandar,Senev ^[1] ; Elisabet,Van Loon ^[2] ; Evelyne,Lerut ^[3] ; Maarten,Coemans ^[2] ; Jasper,Callemeyn ^[2] ; Liesbeth,Daniëls ^[4] ; Johan,Kerkhofs ^[4] ; Priyanka,Koshy ^[3] ; Dirk,Kuypers ^[5] ; Baptiste,Lamarthée ^[2] ; Ben,Sprangers ^[5] ; Claire,Tinel ^[2] ; Amaryllis H,Van Craenenbroeck ^[5] ; Vicky,Van Sandt ^[4] ; Marie-Paule,Emonds ^[1] ; Maarten,Naesens ^[6]

作者单位： KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium; Histocompatibility and Immunogenetics Laboratory (HILA), Belgian Red Cross-Flanders, Mechelen, Belgium. ^[1] KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium. ^[2] Department of Imaging & Pathology, University Hospitals Leuven, Leuven, Belgium. ^[3] Histocompatibility and Immunogenetics Laboratory (HILA), Belgian Red Cross-Flanders, Mechelen, Belgium. ^[4] KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. ^[5] KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address: maarten.naesens@kuleuven.be. ^[6]

关键词 Allograft failure HLA eplet mismatch HLA mismatch T-cell–mediated rejection (TCMR)alloimmune response donor-specific anti-HLA antibodies (HLA-DSA)end-stage renal disease (ESRD)graft dysfunction graft rejection indirect allorecognition kidney biopsy kidney transplantation