Progressive Degeneration and Adaptive Excitability in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons Exposed to HIV-1 Tat and Morphine.

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第一作者： Arianna R S,Lark

第一单位： Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Molecular Medicine Research Building, Room 4040, 1220 East Broad Street, PO Box 980613, Richmond, VA, 23298-0613, USA.

作者： Arianna R S,Lark ^[1] ; Lindsay K,Silva ^[1] ; Sara R,Nass ^[2] ; Michael G,Marone ^[1] ; Michael,Ohene-Nyako ^[1] ; Therese M,Ihrig ^[1] ; William D,Marks ^[1] ; Viktor,Yarotskyy ^[1] ; A,Rory McQuiston ^[3] ; Pamela E,Knapp ^[1] ; Kurt F,Hauser ^[4]

作者单位： Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Molecular Medicine Research Building, Room 4040, 1220 East Broad Street, PO Box 980613, Richmond, VA, 23298-0613, USA. ^[1] PPD®, Part of Thermo Fisher Scientific, Richmond, VA, 23230-3323, USA. ^[2] Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, TX, 75235, USA. ^[3] Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, PO Box 980709, Richmond, VA, 23298-0709, USA. ^[4] Institute for Drug and Alcohol Studies, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA. ^[5] Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Molecular Medicine Research Building, Room 4040, 1220 East Broad Street, PO Box 980613, Richmond, VA, 23298-0613, USA. kurt.hauser@vcuhealth.org. ^[6] Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, PO Box 980709, Richmond, VA, 23298-0709, USA. kurt.hauser@vcuhealth.org. ^[7] Institute for Drug and Alcohol Studies, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA. kurt.hauser@vcuhealth.org. ^[8]

关键词 Dopamine Drd2 and Drd1 receptors Dorsal striatum HIV-1 trans-activator of transcription (Tat)Morphine Neuro-acquired human immunodeficiency syndrome (neuroHIV)Neuroplasticity Phosphorylated-tau Thr205