G-quadruplex stabilizer Tetra-Pt(bpy) disrupts telomere maintenance and impairs FAK-mediated migration of telomerase-positive cells.

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作者： Zhe,Shen ^[1] ; Ruiling,Zheng ^[1] ; Huamao,Yang ^[1] ; Sunhui,Xing ^[1] ; Xiangxiang,Jin ^[1] ; Hao,Yan ^[1] ; Jufan,Zhu ^[2] ; Yanan,Mei ^[1] ; Feng,Lin ^[3] ; Xiaohui,Zheng ^[4]

作者单位： Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, 1210 University Town, Wenzhou 325035, Zhejiang, China. ^[1] Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. ^[2] Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; Department of Gynecology, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. Electronic address: lin801026@163.com. ^[3] Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, 1210 University Town, Wenzhou 325035, Zhejiang, China. Electronic address: zhengxh@wmu.edu.cn. ^[4]

关键词 Anti-migration Anticancer activity Focal adhesion kinase (FAK)G-quadruplex Platinum complex