Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer.

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作者： Semih Can,Akıncılar ^[1] ; Joelle Yi Heng,Chua ^[1] ; Qin Feng,Ng ^[1] ; Claire Hian Tzer,Chan ^[1] ; Zahra,Eslami-S ^[1] ; Kaijing,Chen ^[2] ; Joo-Leng,Low ^[3] ; Surendar,Arumugam ^[1] ; Luay,Aswad ^[2] ; Clarinda,Chua ^[4] ; Iain Beehuat,Tan ^[5] ; Ramanuj,DasGupta ^[4] ; Melissa Jane,Fullwood ^[5] ; Vinay,Tergaonkar ^[3]

作者单位： Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 138673, Singapore. ^[1] Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore. ^[2] Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, A*STAR, 138672, Singapore. ^[3] Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 138672, Singapore. ^[4] Department of Medical Oncology, National Cancer Centre Singapore, 169610, Singapore. ^[5] School of Biological Sciences, Nanyang Technological University, 637551, Singapore. ^[6] Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 119074, Singapore. ^[7] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 117596, Singapore. ^[8]

主题词人类(Humans);染色质(Chromatin);结直肠肿瘤(Colorectal Neoplasms);启动区, 遗传(Promoter Regions, Genetic);末端转移酶端粒(Telomerase);转录, 遗传(Transcription, Genetic)

DOI 10.1093/nar/gkac479

PMID 35697349

发布时间 2023-01-27

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