Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity.

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第一作者： Beatrice,Thier

第一单位： Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.;German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany.

作者： Beatrice,Thier ^[1] ; Fang,Zhao ^[1] ; Simone,Stupia ^[1] ; Alicia,Brüggemann ^[1] ; Johannes,Koch ^[2] ; Nina,Schulze ^[2] ; Susanne,Horn ^[3] ; Christoph,Coch ^[4] ; Gunther,Hartmann ^[5] ; Antje,Sucker ^[1] ; Dirk,Schadendorf ^[1] ; Annette,Paschen ^[6]

作者单位： Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.;German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany. ^[1] Imaging Center Campus Essen, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany. ^[2] Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany. ^[3] Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.;Nextevidence GmbH, Grünwald, Germany. ^[4] Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany. ^[5] Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany annette.paschen@uk-essen.de.;German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany. ^[6]

关键词 immunotherapy lymphocytes, tumor-infiltrating melanoma tumor escape

主题词 CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);免疫, 先天(Immunity, Innate);黑色素瘤(Melanoma);信号传导(Signal Transduction)

DOI 10.1136/jitc-2021-003863

PMID 35697379

发布时间 2022-07-16

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Journal for immunotherapy of cancer

2022年10卷6期

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Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity.

Journal for immunotherapy of cancer

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Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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