Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b.

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作者： Zhihao,Sheng ^[1] ; Qidong,Liu ^[2] ; Chun,Cheng ^[2] ; Mengzhu,Li ^[3] ; Jed,Barash ^[4] ; W Andrew,Kofke ^[5] ; Yuan,Shen ^[6] ; Zhongcong,Xie ^[7]

作者单位： Anesthesia and Brain Research Institute, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. ^[1] Anesthesia and Brain Research Institute, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. ^[2] Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. ^[3] Department of Medicine, Soldiers' Home, Chelsea, MA, USA. ^[4] Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA. ^[5] Anesthesia and Brain Research Institute, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: kmshy@tongji.edu.cn. ^[6] Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address: zxie@mgh.harvard.edu. ^[7]

关键词 Grin2b NMDA receptor autism fentanyl hypermethylation mu opioid receptor neurotoxicity