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Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study.

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第一作者： Asael,Lubotzky

第一单位： Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel.;Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.

作者： Asael,Lubotzky ^[1] ; Ilana,Pelov ^[2] ; Ronen,Teplitz ^[2] ; Daniel,Neiman ^[3] ; Adama,Smadja ^[4] ; Hai,Zemmour ^[3] ; Sheina,Piyanzin ^[3] ; Bracha-Lea,Ochana ^[3] ; Kirsty L,Spalding ^[5] ; Benjamin,Glaser ^[6] ; Ruth,Shemer ^[3] ; Yuval,Dor ^[3] ; Yoav,Kohn ^[7]

作者单位： Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel.;Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel. ^[1] Jerusalem Mental Health Center, Eitanim Psychiatric Hospital, Jerusalem, Israel. ^[2] Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel. ^[3] Hebrew University-Hadassah School of Medicine, Jerusalem, Israel. ^[4] Karolinska Institute, Department of Cell and Molecular Biology Stockholm, Stockholm, Sweden. ^[5] Endocrinology and Metabolism Service, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. ^[6] Jerusalem Mental Health Center, Eitanim Psychiatric Hospital, Jerusalem, Israel.;Hebrew University-Hadassah School of Medicine, Jerusalem, Israel. ^[7]

关键词 DNA methylation biomarker brain biomarkers cfDNA epigenetics genetics genomics human liquid biopsy neuroscience psychosis

医学主题词脑(Brain);DNA甲基化(DNA Methylation);遗传标记(Genetic Markers);人类(Humans);精神病(Psychotic Disorders)

DOI 10.7554/eLife.76391

PMID 35699419

发布时间 2022-07-16

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