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Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer.

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第一作者： Adrià,Sánchez-Morales

第一单位： Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.

作者： Adrià,Sánchez-Morales ^[1] ; Atilla,Biçer ^[2] ; Vasilis,Panagiotopoulos ^[3] ; Selma,Crecente-Garcia ^[1] ; Cristina,Benaiges ^[1] ; Sergi,Bayod ^[4] ; José,Luís Hernández ^[4] ; Félix,Busqué ^[1] ; Minos-Timotheos,Matsoukas ^[5] ; Mercè,Pérez-Riba ^[6] ; Ramon,Alibés ^[7]

作者单位： Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain. ^[1] Genes, Disease and Therapy Program, Human Molecular Genetics Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain. ^[2] Department of Biomedical Engineering, University of West Attica, Egaleo, Athens, 12210, Greece. ^[3] Health & Biomedicine Department of LEITAT Technological Center, Parc Científic de Barcelona, Hèlix building. Baldiri Reixach 15-21, Barcelona, 08028, Spain. ^[4] Department of Biomedical Engineering, University of West Attica, Egaleo, Athens, 12210, Greece. Electronic address: mmatsoukas@uniwa.gr. ^[5] Genes, Disease and Therapy Program, Human Molecular Genetics Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain. Electronic address: mpr@idibell.cat. ^[6] Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain. Electronic address: ramon.alibes@uab.cat. ^[7]

关键词 Calcineurin Docking-based design Druggability evaluation NFAT signaling Inhibitor PxIxIT SAR exploration Triple negative breast cancer

医学主题词动物(Animals);钙神经素(Calcineurin);环孢菌素(Cyclosporine);人类(Humans);小鼠(Mice);NFATC转录因子类(NFATC Transcription Factors);磷酸单酯水解酶类(Phosphoric Monoester Hydrolases)

DOI 10.1016/j.ejmech.2022.114514

PMID 35700596

发布时间 2022-06-23

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准确一般字义偏差语意偏离译文作用小提交