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Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation.

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作者: Yingying,Shen [1] ; Chaojie,Lu [1] ; Zhengbo,Song [2] ; Chenxiao,Qiao [1] ; Jiaoli,Wang [3] ; Jinbiao,Chen [4] ; Chengyan,Zhang [5] ; Xianchang,Zeng [1] ; Zeyu,Ma [1] ; Tao,Chen [1] ; Xu,Li [6] ; Aifu,Lin [7] ; Jufeng,Guo [8] ; Jianli,Wang [9] ; Zhijian,Cai [10]
作者单位: Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China. [1] Department of Medical Oncology, Zhejiang Cancer Hospital, 310022, Hangzhou, China. [2] Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China. [3] Zhejiang University Cancer Centre, 310006, Hangzhou, China. [4] Department of Oncology, Hangzhou Xixi Hospital, 310023, Hangzhou, China. [5] Department of Orthopedics, Musculoskeletal Tumor Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China. [6] School of Life Science, Westlake University, 310024, Hangzhou, China. [7] College of Life Sciences, Zhejiang University, 310058, Hangzhou, China. [8] Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China. [9] Institute of Immunology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, China. jlwang@zju.edu.cn. [10] Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, 310006, Hangzhou, China. jlwang@zju.edu.cn. [11] Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China. caizj@zju.edu.cn. [12]
DOI 10.1038/s41467-022-31141-6
PMID 35701426
发布时间 2022-07-29
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