Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.

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作者： Bo,Qin ^[1] ; Gregory B,Craven ^[2] ; Pengjiao,Hou ^[1] ; Julian,Chesti ^[3] ; Xinran,Lu ^[3] ; Emma S,Child ^[2] ; Rhodri M L,Morgan ^[2] ; Wenchao,Niu ^[4] ; Lina,Zhao ^[4] ; Alan,Armstrong ^[3] ; David J,Mann ^[2] ; Sheng,Cui ^[1]

作者单位： NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100076, China. ^[1] Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. ^[2] Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK. ^[3] CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China. ^[4]

关键词 Allosteric inhibition Covalent fragments EV71 Protease inhibitors SARS-CoV-2

DOI 10.1016/j.apsb.2022.06.002

PMID 35702321

发布时间 2022-10-07

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Acta pharmaceutica Sinica. B

2022年12卷10期

3924-3933页

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Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.

Acta pharmaceutica Sinica. B

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Acta pharmaceutica Sinica. B

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Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.

Acta pharmaceutica Sinica. B

相似文献

Acta pharmaceutica Sinica. B

相关期刊

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