Mechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3.

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作者： Mingqian,Li ^[1] ; Fei,Li ^[2] ; Jiabin,Chen ^[1] ; He,Su ^[3] ; Guanping,Chen ^[1] ; Jili,Cao ^[1] ; Jiacheng,Li ^[2] ; Liyao,Dong ^[2] ; Zhihong,Yu ^[1] ; Yifan,Wang ^[1] ; Chun,Zhou ^[4] ; Yongqiang,Zhu ^[1] ; Qin,Wei ^[5] ; Qun,Li ^[2] ; Kequn,Chai ^[1]

作者单位： Cancer Institute of Integrated tradition Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China. ^[1] College of Life Science, Sichuan Normal University, Chengdu, Sichuan, China. ^[2] The second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guang zhou, Guangdong, China. ^[3] Nursing Department, People's Liberation Army Joint Logistic Support Force 903th Hospital, Hangzhou, Zhejiang, China. ^[4] Key Laboratory of Fermentation Resources and Application in Universities of Sichuan Province, Yibin University, Yibin, Sichuan, China. ^[5]

关键词 phosphodiesterase 3B protein signaling complexes rap guanine nucleotide exchange factor 3 signaling pathway therapeutic cancer target

主题词樟属(Cinnamomum);环AMP(Cyclic AMP);环核苷酸磷酸二酯酶类, 3型(Cyclic Nucleotide Phosphodiesterases, Type 3);鸟嘌呤核苷酸交换因子类(Guanine Nucleotide Exchange Factors);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);植物叶(Plant Leaves)

DOI 10.1002/ptr.7521

PMID 35703011

发布时间 2022-09-09

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