Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression.

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作者： Tim Y,Hou ^[1] ; W Lee,Kraus ^[2]

作者单位： Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. ^[1] Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu. ^[2]

关键词 Breast cancer CP: Molecular biology H3K27 acetylation coregulator enhancer enhancer RNA (eRNA)estrogen receptor alpha (ERα)noncoding RNA p300/CBP pre-mRNA-splicing factor (SPF27/BCAS2)transcription