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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.

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第一作者： Lucy C,Walters

第一单位： Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.

作者： Lucy C,Walters ^[1] ; Daniel,Rozbesky ^[2] ; Karl,Harlos ^[3] ; Max,Quastel ^[1] ; Hong,Sun ^[4] ; Sebastian,Springer ^[5] ; Robert P,Rambo ^[6] ; Fiyaz,Mohammed ^[7] ; E Yvonne,Jones ^[3] ; Andrew J,McMichael ^[8] ; Geraldine M,Gillespie ^[9]

作者单位： Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. ^[1] Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic. ^[2] Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. ^[3] Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China. ^[4] Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany. ^[5] Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK. ^[6] Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. ^[7] Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: andrew.mcmichael@ndm.ox.ac.uk. ^[8] Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: geraldine.gillespie@ndm.ox.ac.uk. ^[9]

关键词 CD8 T?cells CP: Immunology HLA-E MHC Ia MHC-E NK cells NKG2A SAXS T cell receptor VL9 X-ray crystallography small-angle X-ray scatter