Silybin regulates P450s activity by attenuating endoplasmic reticulum stress in mouse nonalcoholic fatty liver disease.

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第一作者： Jing,Wu

第一单位： Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.

作者： Jing,Wu ^[1] ; Yun-Ge,Lou ^[1] ; Xu-le,Yang ^[1] ; Rui,Wang ^[1] ; Ran,Zhang ^[1] ; Ji-Ye,Aa ^[1] ; Guang-Ji,Wang ^[2] ; Yuan,Xie ^[3]

作者单位： Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. ^[1] Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. guangjiwang@hotmail.com. ^[2] Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. yuanxie@cpu.edu.cn. ^[3]

关键词 ER stress Non-alcoholic fatty liver disease P450s Silybin cyt b5 cyt c

主题词小鼠(Mice);动物(Animals);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);小鼠, 近交C57BL(Mice, Inbred C57BL);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);肝(Liver)

DOI 10.1038/s41401-022-00924-4

PMID 35705686

发布时间 2023-01-16

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