A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus.

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第一作者： Nicolas,Melin

第一单位： Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.;Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Switzerland.

作者： Nicolas,Melin ^[1] ; Tural,Yarahmadov ^[1] ; Daniel,Sanchez-Taltavull ^[1] ; Fabienne E,Birrer ^[1] ; Tess M,Brodie ^[1] ; Benoît,Petit ^[2] ; Andrea,Felser ^[3] ; Jean-Marc,Nuoffer ^[3] ; Matteo,Montani ^[4] ; Marie-Catherine,Vozenin ^[2] ; Evelyn,Herrmann ^[5] ; Daniel,Candinas ^[6] ; Daniel M,Aebersold ^[5] ; Deborah,Stroka ^[1]

作者单位： Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.;Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Switzerland. ^[1] Laboratory of Radiation Oncology, Radiation Oncology Service, Department of Oncology, CHUV, Lausanne University Hospital, University of Lausanne, Switzerland. ^[2] Institute of Clinical Chemistry, University of Bern, Switzerland. ^[3] Department of Pathology, University of Bern, Switzerland. ^[4] Department of Radiation Oncology, Department for BioMedical Research, University of Bern, Bern University Hospital, Switzerland. ^[5] Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. ^[6]

关键词 4HNE, 4-hydroxynonenal CV, central vein ECM, extracellular matrix ETC, electron transfer chain GSH, reduced glutathione (glutathione)GSSG, oxidized glutathione (glutathione disulfide)HSCs, hepatic stellate cells IGRT, image-guided radiation therapy IHC, immunohistochemistry IMC, imaging mass cytometry MDA, malondialdehyde RILD, radiation-induced liver disease RNAseq, RNA sequencing ROS ROS, reactive oxygen species RT, radiation therapy SASP, senescence-associated secretory phenotype SNP, single nucleotide polymorphism SOS, sinusoidal obstruction syndrome fibrosis image guided radiation therapy (IGRT)mitochondrial dysfunction mitochondrial-DNA mouse model mtDNA, mitochondrial DNA mtROS, mitochondrial reactive oxygen species p53 radiation-induced liver disease (RILD)rcf, relative centrifuge force senescence sinusoidal obstruction syndrome

DOI 10.1016/j.jhepr.2022.100508

PMID 35712694

发布时间 2024-08-29

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JHEP reports

2022年4卷7期

100508页

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A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus.

JHEP reports

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A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus.

JHEP reports

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