Accurate discrimination of leucine and isoleucine residues by combining continuous digestion with multiple MS<sup>3</sup> spectra integration in protein sequence.

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第一作者： Weijie,Zhang

第一单位： CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China; University of Chinese Academy of Sciences, Beijing, 100039, China.

作者： Weijie,Zhang ^[1] ; Chao,Yang ^[1] ; Jianhui,Liu ^[2] ; Zhen,Liang ^[2] ; Yichu,Shan ^[3] ; Lihua,Zhang ^[4] ; Yukui,Zhang ^[2]

作者单位： CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China; University of Chinese Academy of Sciences, Beijing, 100039, China. ^[1] CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China. ^[2] CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China. Electronic address: shanyichu@dicp.ac.cn. ^[3] CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China. Electronic address: lihuazhang@dicp.ac.cn. ^[4]

关键词 De novo sequencing Leucine and isoleucine discrimination MS(3) based fragmentation Monoclonal antibodies

主题词氨基酸序列(Amino Acid Sequence);抗体, 单克隆(Antibodies, Monoclonal);消化(Digestion);异亮氨酸(Isoleucine);亮氨酸(Leucine);肽类(Peptides);序列分析, 蛋白质(Sequence Analysis, Protein)

DOI 10.1016/j.talanta.2022.123666

PMID 35717752

发布时间 2022-09-07

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