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Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001: A randomized, dose escalation, double-blind phase 1/2 clinical trial in healthy adults.

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第一作者： Rajeka,Lazarus

第一单位： University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.

作者： Rajeka,Lazarus ^[1] ; Christian,Taucher ^[2] ; Claire,Brown ^[3] ; Irena,Čorbic Ramljak ^[4] ; Leon,Danon ^[5] ; Katrin,Dubischar ^[4] ; Christopher J A,Duncan ^[6] ; Susanne,Eder-Lingelbach ^[4] ; Saul N,Faust ^[7] ; Christopher,Green ^[3] ; Karishma,Gokani ^[3] ; Romana,Hochreiter ^[4] ; Johanna Kellett,Wright ^[1] ; Dowan,Kwon ^[1] ; Alexander,Middleditch ^[1] ; Alasdair P S,Munro ^[7] ; Kush,Naker ^[3] ; Florentina,Penciu ^[1] ; David,Price ^[6] ; Benedicte,Querton ^[4] ; Tawassal,Riaz ^[1] ; Amy,Ross-Russell ^[7] ; Amada,Sanchez-Gonzalez ^[6] ; Hayley,Wardle ^[6] ; Sarah,Warren ^[7] ; Adam,Finn ^[8] ; Valneva Phase 1 Trial Group

作者单位： University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. ^[1] Valneva Austria GmbH, Campus Vienna Biocenter 3, Vienna 1030, Austria. Electronic address: christian.taucher@valneva.com. ^[2] NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. ^[3] Valneva Austria GmbH, Campus Vienna Biocenter 3, Vienna 1030, Austria. ^[4] Department of Engineering Mathematics, University of Bristol, Bristol, UK. ^[5] Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle, UK. ^[6] NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. ^[7] University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK; Schools of Population Health Sciences and Cellular and Molecular Medicine, University of Bristol, Bristol, UK. ^[8]

关键词 Adjuvanted vaccine COVID-19 Coronavirus CpG 1018 Inactivated vaccine Neutralizing antibody RBD-binding IgG antibody S protein binding IgG antibody SARS-CoV-2 Whole-virus vaccine

医学主题词成年人(Adult);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);双盲法(Double-Blind Method);人类(Humans);免疫法, 被动(Immunization, Passive)

DOI 10.1016/j.jinf.2022.06.009

PMID 35718205

发布时间 2023-05-22

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