换一批Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma.
第一作者：
Christine,Skaggs
第一单位：
Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
作者：
关键词
ANOVA, A one-way analysis of varianceAUC, area under the curveAntiviralCE, collision energyCES1, carboxylesterase-1CES2, carboxylesterase-2CV, coefficient of variationDMSO, dimethyl sulfoxideEC50, half maximum effective concentrationECMO, extracorporal membrane oxygenationH-ESI, heated electrospray ionizationIRB, institutional review boardIS, internal standardInc, IncorporatedLC-MS/MS, liquid chromatography–mass spectrometryLLC, Limited Liability CompanyLLOQ, lower limit of quantitationLOD, limit of detectionMP, monophosphateMass spectrometryPD, pharmacodynamicsPK, pharmacokineticsPS-MS/MS, paper spray–mass spectrometryPaper sprayQC, quality controlQC-LLOQ, quality control-lower limit of quantificationR2, coefficient of determinationRF, radio frequencyRemdesivirS/B, Signal-to-BlankSARS-CoV-2SIL, stable isotopically-labeledSS, spiking solutionV, voltskV, kilovoltsm/z, mass-to-chargemL, milliliterng, nanogramtherapeutic drug monitoring, TDMμL, microliterμg, microgram
DOI
10.1016/j.jmsacl.2022.06.001
PMID
35721272
发布时间
2023-05-19
基金项目
L40 AI147213/AI/NIAID NIH HHS/United States
R25 AI147376/AI/NIAID NIH HHS/United States
T32 HD069047/HD/NICHD NIH HHS/United States
- 浏览6
Journal of mass spectrometry and advances in the clinical lab
2022年25卷
27-35页
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