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Escherichia coli cell factories with altered chromosomal replication scenarios exhibit accelerated growth and rapid biomass production.

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第一作者： Hee Jin,Yang

第一单位： Department of Systems Biology, Division of Life Sciences, Institute for Life Science and Biotechnology, and Microbiome Initiative, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

作者： Hee Jin,Yang ^[1] ; Kitae,Kim ^[1] ; Soon-Kyeong,Kwon ^[2] ; Jihyun F,Kim ^[3]

作者单位： Department of Systems Biology, Division of Life Sciences, Institute for Life Science and Biotechnology, and Microbiome Initiative, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. ^[1] Department of Systems Biology, Division of Life Sciences, Institute for Life Science and Biotechnology, and Microbiome Initiative, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.;Division of Applied Life Science (BK21), Gyeongsang National University, 501 Jinju-daero, Jinju-si, 52828, Gyeongsangnam-do, Republic of Korea. ^[2] Department of Systems Biology, Division of Life Sciences, Institute for Life Science and Biotechnology, and Microbiome Initiative, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. jfk1@yonsei.ac.kr.;Department of Systems Biology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. jfk1@yonsei.ac.kr. ^[3]

关键词 Aberrant replication origins Biomass increase Cell cycle Ectopic replication origins Genomic architecture engineering Multiple replication origins Replication profile Replication strategy

医学主题词生物量(Biomass);染色体, 细菌(Chromosomes, Bacterial);DNA复制(DNA Replication);DNA, 细菌(DNA, Bacterial);大肠杆菌(Escherichia coli);复制起点(Replication Origin)

DOI 10.1186/s12934-022-01851-z

PMID 35729580

发布时间 2022-07-16

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