Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii.

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作者： Subhasree,Roy ^[1] ; Vivek,Junghare ^[2] ; Shanta,Dutta ^[1] ; Saugata,Hazra ^[2] ; Sulagna,Basu ^[3]

作者单位： Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India. ^[1] Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India. ^[2] Centre for Nanotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India. ^[3]

关键词 3D modeling Acinetobacter baumannii AdeABC AdeRS India PA?N antimicrobial resistance carbapenem resistance molecular docking neonatal sepsis

主题词卡巴配能类(Carbapenems);鲍氏不动杆菌(Acinetobacter baumannii);膜转运蛋白质类(Membrane Transport Proteins);细菌蛋白质类(Bacterial Proteins);抗菌药(Anti-Bacterial Agents);突变(Mutation)

DOI 10.1128/msystems.00217-22

PMID 35735748

发布时间 2022-12-22

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2022年7卷4期

e0021722页

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Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii.

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Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii.

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