Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease.

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第一作者： Gabriella,Assante

第一单位： Institute of Hepatology, Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.;King's College London, Faculty of Life Sciences and Medicine, London, UK.

作者： Gabriella,Assante ^[1] ; Sriram,Chandrasekaran ^[2] ; Stanley,Ng ^[3] ; Aikaterini,Tourna ^[1] ; Carolina H,Chung ^[4] ; Kowsar A,Isse ^[1] ; Jasmine L,Banks ^[5] ; Ugo,Soffientini ^[1] ; Celine,Filippi ^[6] ; Anil,Dhawan ^[6] ; Mo,Liu ^[7] ; Steven G,Rozen ^[7] ; Matthew,Hoare ^[8] ; Peter,Campbell ^[3] ; J William O,Ballard ^[9] ; Nigel,Turner ^[5] ; Margaret J,Morris ^[10] ; Shilpa,Chokshi ^[1] ; Neil A,Youngson ^[11]

作者单位： Institute of Hepatology, Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.;King's College London, Faculty of Life Sciences and Medicine, London, UK. ^[1] Program in Chemical Biology, University of Michigan, Ann Arbor, MI, 48109, USA.;Center for Bioinformatics and Computational Medicine, Ann Arbor, MI, 48109, USA.;Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.;Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. ^[2] Wellcome Trust Sanger Institute, Cambridge, UK. ^[3] Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA. ^[4] UNSW Sydney, Sydney, Australia.;Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. ^[5] Institute of Liver Studies, King's College Hospital, London, UK. ^[6] Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. ^[7] CRUK Cambridge Institute, Cambridge, UK.;Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. ^[8] Department of Ecology, Environment and Evolution, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia. ^[9] UNSW Sydney, Sydney, Australia. ^[10] Institute of Hepatology, Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK. n.youngson@researchinliver.org.uk.;King's College London, Faculty of Life Sciences and Medicine, London, UK. n.youngson@researchinliver.org.uk.;UNSW Sydney, Sydney, Australia. n.youngson@researchinliver.org.uk. ^[11]

关键词 ARLD Hepatocellular carcinoma Histone acetylation NAFLD Steatosis Telomerase