Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma-A Histopathological Study.

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作者： Miguel A,Ortega ^[1] ; Oscar,Fraile-Martinez ^[2] ; Cielo,García-Montero ^[3] ; Sandra,Borja-Vergel ^[1] ; Diego,Torres-Carranza ^[2] ; Leonel,Pekarek ^[1] ; Coral Bravo,Arribas ^[2] ; Juan A,De León-Luis ^[1] ; Cristina,Sánchez-Rojo ^[1] ; Miguel Angel,Alvarez-Mon ^[1] ; Natalio,García-Honduvilla ^[2] ; Julia,Buján ^[4] ; Santiago,Coca ^[5] ; Melchor,Alvarez-Mon ^[6] ; Miguel A,Saez ^[5] ; Luis G,Guijarro ^[6]

作者单位： Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain. ^[1] Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain. ^[2] Cancer Registry and Pathology Department, Principe de Asturias University Hospital, 28806 Alcala de Henares, Spain. ^[3] Oncology Service, Guadalajara University Hospital, 19002 Guadalajara, Spain. ^[4] Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain. ^[5] Health Research Institute Gregorio Marañón, 28009 Madrid, Spain. ^[6] Department of Obstetrics and Gynecology, Central University Hospital of Defence-UAH Madrid, 28801 Alcala de Henares, Spain. ^[7] Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine, University Hospital Príncipe de Asturias, 28806 Alcala de Henares, Spain. ^[8] Pathological Anatomy Service, Central University Hospital of Defence-UAH Madrid, 28801 Alcala de Henares, Spain. ^[9] Unit of Biochemistry and Molecular Biology, Department of System Biology, University of Alcalá, 28801 Alcala de Henares, Spain. ^[10]

关键词 breast cancer (BC)cyclin D1 cyclooxygenase 2 (COX-2)insulin receptor substrate 4 (IRS-4)invasive lobular carcinoma (ILC)retinoblastoma protein 1 (Rb1)