Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches.

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第一作者： Shashank M,Patil

第一单位： Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, India.

作者： Shashank M,Patil ^[1] ; Reshma Mary,Martiz ^[1] ; A M,Satish ^[2] ; Abdullah M,Shbeer ^[3] ; Mohammed,Ageel ^[3] ; Mohammed,Al-Ghorbani ^[4] ; Lakshmi,Ranganatha ^[5] ; Saravanan,Parameswaran ^[1] ; Ramith,Ramu ^[1]

作者单位： Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, India. ^[1] Department of Pharmacology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India. ^[2] Department of Surgery, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia. ^[3] Department of Chemistry, College of Science and Arts, Taibah University, Madina 41477, Saudi Arabia.;Department of Chemistry, College of Education, Thamar University, Thamar 425897, Yemen. ^[4] Department of Chemistry, The National Institute of Engineering, Mysuru 570008, India. ^[5]

关键词 coumarin diabetes mellitus molecular modeling postprandial hyperglycemia α-amylase α-glucosidase

主题词香豆素类(Coumarins);人类(Humans);高血糖症(Hyperglycemia);降血糖药(Hypoglycemic Agents);锌(Zinc);α淀粉酶类(alpha-Amylases);α葡糖苷酶类(alpha-Glucosidases)

DOI 10.3390/molecules27123888

PMID 35745030

发布时间 2024-08-30

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