Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model.

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作者： Ming,Ji ^[1] ; Wenliang,Gong ^[1] ; Siman,Wang ^[1] ; Dianjun,Zhang ^[1] ; Binjie,Chen ^[1] ; Xinyu,Li ^[1] ; Xiafang,Wu ^[1] ; Lulu,Cui ^[1] ; Yuliang,Feng ^[1] ; Alexei,Verkhratsky ^[2] ; Baoman,Li ^[3]

作者单位： Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. ^[1] Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. Alexej.Verkhratsky@manchester.ac.uk. ^[2] Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Alexej.Verkhratsky@manchester.ac.uk. ^[3] Achucarro Center for Neuroscience, IKERBASQUE, 48011, Bilbao, Spain. Alexej.Verkhratsky@manchester.ac.uk. ^[4] Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, 01102, Vilnius, Lithuania. Alexej.Verkhratsky@manchester.ac.uk. ^[5] Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. bmli@cmu.edu.cn. ^[6]

关键词 Astrocytes Leptin NLRP3 inflammasome Post-traumatic stress disorder STAT3

主题词小鼠(Mice);动物(Animals);炎性体(Inflammasomes);星形细胞(Astrocytes);应激障碍, 创伤后(Stress Disorders, Post-Traumatic);瘦素(Leptin);恐惧(Fear)

DOI 10.1007/s11064-022-03655-4

PMID 35750877

发布时间 2023-03-23

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