Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model.

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作者： Ramón A,Juste ^[1] ; Elisa,Ferreras-Colino ^[2] ; José,de la Fuente ^[3] ; Mercedes,Domínguez ^[3] ; María A,Risalde ^[4] ; Lucas,Domínguez ^[5] ; Alejandro,Cabezas-Cruz ^[6] ; Christian,Gortázar ^[7]

作者单位： Animal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio, Bizkaia, Spain. ^[1] NySA, Servicio Regional de Investigación y Desarrollo Agroalimentario, Villaviciosa, Asturias, Spain. ^[2] SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain. ^[3] Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. ^[4] Unidad de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. ^[5] Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain. ^[6] CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. ^[7] VISAVET Health Surveillance Centre, Complutense University of Madrid, Madrid, Spain. ^[8] Department of Animal Health, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain. ^[9] UMR BIPAR, INRAE, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France. ^[10]

关键词 cross-protection glycan alpha-Gal heat-inactivated Mycobacterium bovis macrophages trained innate immunity