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Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines.

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第一作者： Steven E,Guard

第一单位： Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA.

作者： Steven E,Guard ^[1] ; Douglas A,Chapnick ^[2] ; Zachary C,Poss ^[1] ; Christopher C,Ebmeier ^[1] ; Jeremy,Jacobsen ^[1] ; Travis,Nemkov ^[3] ; Kerri A,Ball ^[1] ; Kristofor J,Webb ^[1] ; Helen L,Simpson ^[1] ; Stephen,Coleman ^[1] ; Eric,Bunker ^[2] ; Adrian,Ramirez ^[2] ; Julie A,Reisz ^[3] ; Robert,Sievers ^[4] ; Michael H B,Stowell ^[1] ; Angelo,D'Alessandro ^[3] ; Xuedong,Liu ^[2] ; William M,Old ^[5]

作者单位： Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA. ^[1] Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, USA. ^[2] Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado, USA. ^[3] Department of Chemistry and Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, Colorado, USA. ^[4] Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA. Electronic address: william.old@colorado.edu. ^[5]

关键词 FRET biosensor cannabidiol high-content screening lipidomics metabolomics multiomics phosphoproteomics proteomics systems pharmacology transcriptomics