Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.

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第一作者： Stefania,Cocco

第一单位： Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. s.cocco@istitutotumori.na.it.

作者： Stefania,Cocco ^[1] ; Alessandra,Leone ^[2] ; Maria Serena,Roca ^[3] ; Rita,Lombardi ^[3] ; Michela,Piezzo ^[4] ; Roberta,Caputo ^[4] ; Chiara,Ciardiello ^[3] ; Susan,Costantini ^[3] ; Francesca,Bruzzese ^[5] ; Maria José,Sisalli ^[6] ; Alfredo,Budillon ^[3] ; Michelino,De Laurentiis ^[4]

作者单位： Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. s.cocco@istitutotumori.na.it. ^[1] Experimental Pharmacology Unit, Laboratories of Naples and Mercogliano (AV), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. a.leone@istitutotumori.na.it. ^[2] Experimental Pharmacology Unit, Laboratories of Naples and Mercogliano (AV), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. ^[3] Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. ^[4] Animal Facility, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy. ^[5] Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy. ^[6]

关键词 Autophagy Breast Cancer Chloroquine PI3K/AKT/mTOR inhibitors TNBC