Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase.

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第一作者： Felipe A M,Otsuka

第一单位： Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden.;Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.

作者： Felipe A M,Otsuka ^[1] ; Sinisa,Bjelic ^[2]

作者单位： Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden.;Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. ^[1] Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden. ^[2]

关键词 Abl1 ancestral reconstruction conformational energy kinase resistant positions

主题词氨基酸类(Amino Acids);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);白血病, 髓系, 慢性, BCR-ABL阳性(Leukemia, Myelogenous, Chronic, BCR-ABL Positive);白血病, 髓样, 慢性期(Leukemia, Myeloid, Chronic-Phase);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-abl(Proto-Oncogene Proteins c-abl)

DOI 10.1002/pro.4354

PMID 35762721

发布时间 2024-08-30

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