Rationale and Design of the Cardiac CARE Trial: A Randomized Trial of Troponin-Guided Neurohormonal Blockade for the Prevention of Anthracycline Cardiotoxicity.

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作者： Peter A,Henriksen ^[1] ; Peter,Hall ^[2] ; Olga,Oikonomidou ^[2] ; Iain R,MacPherson ^[3] ; Morag,Maclean ^[4] ; Steff,Lewis ^[4] ; Heather,McVicars ^[2] ; Angus,Broom ^[5] ; Fiona,Scott ^[5] ; Pam,McKay ^[6] ; Annabel,Borley ^[7] ; Clare,Rowntree ^[8] ; Simon,Lord ^[9] ; Graham,Collins ^[10] ; John,Radford ^[11] ; Amy,Guppy ^[12] ; John R,Payne ^[13] ; David E,Newby ^[1] ; Nick L,Mills ^[1] ; Ninian N,Lang ^[14]

作者单位： BHF Centre for Cardiovascular Science (P.A.H., D.E.N., N.L.M.), University of Edinburgh, United Kingdom. ^[1] Cancer Research UK, Edinburgh Centre, MRC Institute Genetics and Molecular Medicine (P.H., O.O., H.M.), University of Edinburgh, United Kingdom. ^[2] Institute of Cancer Sciences (I.R.M.), University of Glasgow, United Kingdom. ^[3] Edinburgh Clinical Trials Unit (M.M., S. Lewis), University of Edinburgh, United Kingdom. ^[4] Department of Haematology, Western General Hospital, Edinburgh, United Kingdom (A. Broom, F.S.). ^[5] Department of Haematology, Beatson Oncology Centre, Glasgow, United Kingdom (P.M.). ^[6] Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, United Kingdom (A. Borley). ^[7] University Hospital of Wales, Cardiff, United Kingdom (C.R.). ^[8] Department of Oncology, University of Oxford, United Kingdom (S. Lord). ^[9] Oxford Cancer and Hematology Centre, Churchill Hospital, United Kingdom (G.C.). ^[10] University of Manchester and Christie NHS Foundation, United Kingdom (J.R.). ^[11] Mount Vernon Cancer Centre, Middlesex, United Kingdom (A.G.). ^[12] Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.R.P.). ^[13] Institute of Cardiovascular and Medical Sciences (N.N.L.), University of Glasgow, United Kingdom. ^[14]

关键词 anthracyclines lymphoma magnetic resonance imaging troponin ventricular dysfunction