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Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples.

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作者单位: Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. [1] (Formerly) Department of Pathology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, 43614, USA.;Lucas County Coroner's Office, 2595 Arlington Ave, Toledo, OH, 43614, USA. [2] Immuneering Corporation, 245 Main St, Cambridge, MA, 02142, USA. [3] Astrazeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA, 02451, USA. [4] Research and Development, Burning Rock Biotech, Shanghai, 201114, China. [5] (Formerly) Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. [6] Icahn Institute and Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY, 10029, USA. [7] Illumina Inc., 5200 Illumina Way, San Diego, CA, 92122, USA. [8] Thermo Fisher Scientific, 110 Miller Ave, Ann Arbor, MI, 48104, USA. [9] Agilent Technologies, 11011 N Torrey Pines Rd, La Jolla, CA, 92037, USA. [10] Department of Pathology, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USA. [11] Department of Pathology, Strata Oncology, Inc., Ann Arbor, MI, 48103, USA. [12] Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. [13] Department of Medicine, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, 43614, USA. [14] Accugenomics, Inc., 1410 Commonwealth Drive, Suite 105, Wilmington, NC, 20403, USA. [15] Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.;EATRIS ERIC- European Infrastructure for Translational Medicine, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands. [16] Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.;Stanford Genome Technology Center, Stanford University, Palo Alto, CA, 94304, USA. [17] Department of Information Science, University of Arkansas at Little Rock, 2801 S. Univ. Ave, Little Rock, AR, 72204, USA. [18] Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, 10065, USA. [19] Market & Application Development Bioinformatics, Roche Sequencing Solutions Inc., 4300 Hacienda Dr, Pleasanton, CA, 94588, USA. [20] Q2 Solutions - EA Genomics, 5927 S Miami Blvd, Morrisville, NC, 27560, USA. [21] Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. [22] State Key Laboratory of Genetic Engineering, School of Life Sciences and Shanghai Cancer Hospital/Cancer Institute, Fudan University, Shanghai, 200438, China.;Human Phenome Institute, Fudan University, Shanghai, 201203, China.;Fudan-Gospel Joint Research Center for Precision Medicine, Fudan University, Shanghai, 200438, China. [23] Departments of Medicine, Pathology, and Cancer Biology, College of Medicine and Life Sciences, University of Toledo Health Sciences Campus, 3000 Arlington Ave, Toledo, OH, 43614, USA. james.willey2@utoledo.edu. [24] Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. joshua.xu@fda.hhs.gov. [25]
DOI 10.1186/s13059-022-02709-8
PMID 35768876
发布时间 2024-08-30
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