Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.
作者:
Ignasius,Joanito [1]
;
Pratyaksha,Wirapati [2]
;
Nancy,Zhao [1]
;
Zahid,Nawaz [1]
;
Grace,Yeo [1]
;
Fiona,Lee [1]
;
Christine L P,Eng [3]
;
Dominique Camat,Macalinao [1]
;
Merve,Kahraman [3]
;
Harini,Srinivasan [3]
;
Vairavan,Lakshmanan [1]
;
Sara,Verbandt [1]
;
Petros,Tsantoulis [3]
;
Nicole,Gunn [3]
;
Prasanna Nori,Venkatesh [4]
;
Zhong Wee,Poh [5]
;
Rahul,Nahar [6]
;
Hsueh Ling Janice,Oh [3]
;
Jia Min,Loo [1]
;
Shumei,Chia [1]
;
Lih Feng,Cheow [7]
;
Elsie,Cheruba [8]
;
Michael Thomas,Wong [8]
;
Lindsay,Kua [1]
;
Clarinda,Chua [1]
;
Andy,Nguyen [9]
;
Justin,Golovan [9]
;
Anna,Gan [8]
;
Wan-Jun,Lim [3]
;
Yu Amanda,Guo [3]
;
Choon Kong,Yap [10]
;
Brenda,Tay [10]
;
Yourae,Hong [1]
;
Dawn Qingqing,Chong [3]
;
Aik-Yong,Chok [1]
;
Woong-Yang,Park [1]
;
Shuting,Han [3]
;
Mei Huan,Chang [11]
;
Isaac,Seow-En [3]
;
Cherylin,Fu [7]
;
Ronnie,Mathew [12]
;
Ee-Lin,Toh [11]
;
Lewis Z,Hong [3]
;
Anders Jacobsen,Skanderup [12]
;
Ramanuj,DasGupta [12]
;
Chin-Ann Johnny,Ong [12]
;
Kiat Hon,Lim [12]
;
Emile K W,Tan [12]
;
Si-Lin,Koo [13]
;
Wei Qiang,Leow [8]
;
Sabine,Tejpar [1]
;
Shyam,Prabhakar [1]
;
Iain Beehuat,Tan [14]
作者单位:
Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
[1]
Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
[2]
National Cancer Centre, Singapore, Singapore.
[3]
Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.
[4]
Hôpitaux Universitaires de Genève, Geneva, Switzerland.
[5]
University of Geneva, Geneva, Switzerland.
[6]
Duke-National University of Singapore Medical School, Singapore, Singapore.
[7]
MSD International GmbH (Singapore Branch), Singapore, Singapore.
[8]
National University of Singapore, Singapore, Singapore.
[9]
NantOmics, Rockville, MD, USA.
[10]
Samsung Genome Institute, Samsung Medical Center, Seoul, Korea.
[11]
Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
[12]
EL Toh Colorectal & Minimally Invasive Surgery, Singapore, Singapore.
[13]
Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
[14]
Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore, Singapore.
[15]
Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.
[16]
SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.
[17]
SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.
[18]
Institute of Molecular and Cell Biology, A*STAR Research Entities, Singapore, Singapore.
[19]
Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
[20]
Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium. sabine.tejpar@uzleuven.be.
[21]
Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. prabhakars@gis.a-star.edu.sg.
[22]
Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.
[23]
National Cancer Centre, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.
[24]
Duke-National University of Singapore Medical School, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.
[25]
主题词
结直肠肿瘤(Colorectal Neoplasms);上皮细胞(Epithelial Cells);人类(Humans);微卫星不稳定性(Microsatellite Instability);微卫星重复(Microsatellite Repeats);肿瘤, 腺和上皮(Neoplasms, Glandular and Epithelial)
DOI
10.1038/s41588-022-01100-4
PMID
35773407
发布时间
2022-10-20
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Nature genetics
Nature genetics
963-975页
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