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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.

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作者单位: Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [1] Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] National Cancer Centre, Singapore, Singapore. [3] Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium. [4] Hôpitaux Universitaires de Genève, Geneva, Switzerland. [5] University of Geneva, Geneva, Switzerland. [6] Duke-National University of Singapore Medical School, Singapore, Singapore. [7] MSD International GmbH (Singapore Branch), Singapore, Singapore. [8] National University of Singapore, Singapore, Singapore. [9] NantOmics, Rockville, MD, USA. [10] Samsung Genome Institute, Samsung Medical Center, Seoul, Korea. [11] Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore. [12] EL Toh Colorectal & Minimally Invasive Surgery, Singapore, Singapore. [13] Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore. [14] Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore, Singapore. [15] Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore. [16] SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. [17] SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. [18] Institute of Molecular and Cell Biology, A*STAR Research Entities, Singapore, Singapore. [19] Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore. [20] Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium. sabine.tejpar@uzleuven.be. [21] Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. prabhakars@gis.a-star.edu.sg. [22] Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. iain.tan.b.h@singhealth.com.sg. [23] National Cancer Centre, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg. [24] Duke-National University of Singapore Medical School, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg. [25]
DOI 10.1038/s41588-022-01100-4
PMID 35773407
发布时间 2022-10-20
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