Formulation of the novel structure curcumin derivative-loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening <i>in vitro</i>.

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作者： Ke,Li ^[1] ; Chao,Pi ^[2] ; Jie,Wen ^[3] ; Yingmeng,He ^[1] ; Jiyuan,Yuan ^[2] ; Hongping,Shen ^[3] ; Wenmei,Zhao ^[1] ; Mingtang,Zeng ^[2] ; Xinjie,Song ^[3] ; Robert J,Lee ^[2] ; Yumeng,Wei ^[3] ; Ling,Zhao ^[2]

作者单位： Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy of Southwest Medical University, Luzhou, China. ^[1] Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, P.R. China. ^[2] Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, P.R. China. ^[3] Clinical Trial Center, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, P.R China. ^[4] School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, Zhejiang, China. ^[5] Department of Food Science and Technology, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea. ^[6] Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA. ^[7]

关键词 Curcumin anti-tumor activity derivative solid lipid nanoparticle

主题词抗肿瘤药(Antineoplastic Agents);姜黄素(Curcumin);药物载体(Drug Carriers);脂类(Lipids);脂质体(Liposomes);纳米粒子(Nanoparticles);粒子大小(Particle Size)

DOI 10.1080/10717544.2022.2092235

PMID 35775475

发布时间 2023-06-07

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