Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay.

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作者： Michael A,Partridge ^[1] ; Jihua,Chen ^[2] ; Elif Kabuloglu,Karayusuf ^[2] ; Thanoja,Sirimanne ^[2] ; Colin,Stefan ^[2] ; Ching Ha,Lai ^[2] ; Meghna,Gathani ^[2] ; Lisa,DeStefano ^[2] ; Michal,Rozanski ^[2] ; Sean,McAfee ^[2] ; Manoj,Rajadhyaksha ^[2] ; Matthew D,Andisik ^[3] ; Albert,Torri ^[2] ; Giane,Sumner ^[2]

作者单位： Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. michael.partridge@regeneron.com. ^[1] Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. ^[2] Alexion-AstraZeneca Rare Disease Unit, 100 College St, New Haven, CT, 06510, USA. ^[3]

关键词 Anti-drug antibody (ADA)Autoantibody IgG4 Immunogenicity Monoclonal antibody therapeutic Pre-existing antibody

主题词抗体, 单克隆(Antibodies, Monoclonal);表位(Epitopes);人类(Humans);免疫球蛋白G(Immunoglobulin G)

DOI 10.1208/s12248-022-00729-7

PMID 35778641

发布时间 2022-07-25

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