P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine.

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第一作者： Yajuan,Wang

第一单位： Department of Neurology, Renmin Hospital of Wuhan University, 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, Hubei Province, China.

作者： Yajuan,Wang ^[1] ; Zhengming,Shan ^[1] ; Lily,Zhang ^[1] ; Shanghua,Fan ^[1] ; Yanjie,Zhou ^[1] ; Luyu,Hu ^[1] ; Yue,Wang ^[1] ; Weidong,Li ^[1] ; Zheman,Xiao ^[2]

作者单位： Department of Neurology, Renmin Hospital of Wuhan University, 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, Hubei Province, China. ^[1] Department of Neurology, Renmin Hospital of Wuhan University, 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, Hubei Province, China. zmxiao@whu.edu.cn. ^[2]

关键词 Apoptosis Cognitive impairment Migraine NLRP3 inflammasome Neuroinflammation P2X7 receptor Pyroptosis

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);小鼠(Mice);偏头痛(Migraine Disorders);受体, 嘌呤能P2X7(Receptors, Purinergic P2X7);信号传导(Signal Transduction)

DOI 10.1186/s10194-022-01442-8

PMID 35780081

发布时间 2022-07-20

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