Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression.

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作者： Lin,Zhao ^[1] ; Yingli,Yu ^[2] ; Li,Li ^[1] ; Jiarui,Wang ^[1] ; Jing,Wang ^[1] ; Shijia,Su ^[1] ; Jingyi,Ding ^[1] ; Yue,Zhang ^[3] ; Anhong,Wang ^[4] ; Kun,Zhou ^[5]

作者单位： Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. ^[1] Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: yuguyu88@sina.com. ^[2] Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. ^[3] Gansu Provincial Hospital, Lanzhou, 731600, China. ^[4] Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: z.k.ken@263.net. ^[5]

关键词 Akt Hepatotoxicity Isobavachalcone Mitochondrial damage Oxidative stress

主题词细胞凋亡(Apoptosis);查耳酮类(Chalcones);人类(Humans);线粒体(Mitochondria);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);活性氧(Reactive Oxygen Species);呼吸(Respiration)

DOI 10.1016/j.toxicon.2022.06.018

PMID 35780971

发布时间 2022-08-16

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