An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk.

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作者： Tao,Zhang ^[1] ; Zachary,Applebee ^[1] ; Peng,Zou ^[2] ; Zhen,Wang ^[1] ; Erika Solano,Diaz ^[3] ; Yanyan,Li ^[4]

作者单位： Department of Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME 04401, United States of America. ^[1] Daiichi Sankyo, Inc., 211 Mount Airy Road, Basking Ridge, NJ 07920, United States of America. ^[2] Department of Biomedical Engineering, SUNY-Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, United States of America. ^[3] College of Science and Humanities, Husson University, Bangor, ME 04401, USA. Current affiliation: School of Food and Agriculture, College of Natural Sciences, Forestry, and Agriculture, University of Maine, Orono, ME 04469, USA. ^[4]

关键词 Drug transport ER, extraction ratio FITC, fluorescein isothiocyanate GH, growth hormone IVIVE, in vitro to in vivo extrapolation M/P ratio M/P ratio, milk to plasma ratio MEC, mammary epithelial cell Mammary epithelial cell P-gp, p-glycoprotein Permeability TEER, trans-epithelial electrical resistance TEM, transmission electron microscopy TJ, tight junction

DOI 10.1016/j.ijpx.2022.100122

PMID 35789754

发布时间 2022-07-16

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International journal of pharmaceutics

2022年4卷

100122页

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An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk.

International journal of pharmaceutics

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International journal of pharmaceutics

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An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk.

International journal of pharmaceutics

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International journal of pharmaceutics

相关期刊

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