A pH-Driven Small-Molecule Nanotransformer Hijacks Lysosomes and Overcomes Autophagy-Induced Resistance in Cancer.

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作者： Zhao,Ma ^[1] ; Kai,Lin ^[2] ; Menghuan,Tang ^[3] ; Mythili,Ramachandran ^[3] ; Reng,Qiu ^[3] ; Jin,Li ^[3] ; Lucas N,Solano ^[3] ; Yanyu,Huang ^[3] ; Cristabelle,De Souza ^[3] ; Sara,Abou-Adas ^[3] ; Bai,Xiang ^[3] ; Lanwei,Zhang ^[4] ; Minyong,Li ^[5] ; Yuanpei,Li ^[3]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University, Jinan, Shandong, 250012, China.;Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA. ^[1] Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.;College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, 266003, China. ^[2] Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA. ^[3] College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, 266003, China. ^[4] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University, Jinan, Shandong, 250012, China. ^[5]

关键词 Autophagy Lysosomes Nanofibrils Photodynamic Therapy Transformable Nanoparticles

主题词抗肿瘤药(Antineoplastic Agents);自噬(Autophagy);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);溶酶体(Lysosomes);肿瘤(Neoplasms)

DOI 10.1002/anie.202204567

PMID 35791769

发布时间 2024-09-14

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准确一般字义偏差语意偏离译文作用小提交