首页> Toxicology> MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).

MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).

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第一作者： Simin,Zhao

第一单位： Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, and The Second Affiliated Hospital, Hengyang Medical School,University of South China, Hengyang City, Hunan Province 421001, PR China.

作者： Simin,Zhao ^[1] ; Yao,Tan ^[1] ; Jianning,Qin ^[1] ; Haiqiang,Xu ^[1] ; Lingyun,Liu ^[1] ; Hengquan,Wan ^[1] ; Chi,Zhang ^[1] ; Wenjing,Fan ^[2] ; Shunlin,Qu ^[3]

作者单位： Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, and The Second Affiliated Hospital, Hengyang Medical School,University of South China, Hengyang City, Hunan Province 421001, PR China. ^[1] Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, and The Second Affiliated Hospital, Hengyang Medical School,University of South China, Hengyang City, Hunan Province 421001, PR China. Electronic address: fanwj2008168@126.com. ^[2] Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, and The Second Affiliated Hospital, Hengyang Medical School,University of South China, Hengyang City, Hunan Province 421001, PR China. Electronic address: qushunlin78@126.com. ^[3]

关键词 Cardiomyocyte IL-1β Pyroptosis SPI1 caspase-1 miR-223–3p

医学主题词半胱氨酸天冬氨酸蛋白酶1(Caspase 1);糖尿病心肌病(Diabetic Cardiomyopathies);人类(Humans);炎性体(Inflammasomes);微RNAs(MicroRNAs);肌细胞, 心脏(Myocytes, Cardiac)

DOI 10.1016/j.tox.2022.153252

PMID 35792203

发布时间 2022-07-28

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