Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

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作者： Élise,Rouleau-Turcotte ^[1] ; Dragomir B,Krastev ^[2] ; Stephen J,Pettitt ^[2] ; Christopher J,Lord ^[2] ; John M,Pascal ^[3]

作者单位： Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. ^[1] CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London SW3 6JB, UK. ^[2] Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: john.pascal@umontreal.ca. ^[3]

关键词 ADP-ribose DNA strand breaks PARP enzymes PARP inhibitors PARP1 allostery poly(ADP-ribose)

主题词催化域(Catalytic Domain);DNA损伤(DNA Damage);DNA修复(DNA Repair);NAD(NAD);聚腺苷二磷酸酯核糖(Poly Adenosine Diphosphate Ribose)

DOI 10.1016/j.molcel.2022.06.011

PMID 35793673

发布时间 2024-02-10

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