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Multi-Modal Single-Cell Sequencing Identifies Cellular Immunophenotypes Associated With Juvenile Dermatomyositis Disease Activity.

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第一作者： Jessica,Neely

第一单位： Division of Pediatric Rheumatology, Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States.

作者： Jessica,Neely ^[1] ; George,Hartoularos ^[2] ; Daniel,Bunis ^[3] ; Yang,Sun ^[4] ; David,Lee ^[5] ; Susan,Kim ^[1] ; Chun Jimmie,Ye ^[6] ; Marina,Sirota ^[7]

作者单位： Division of Pediatric Rheumatology, Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States. ^[1] Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, CA, United States.;Institute of Human Genetics, University of California San Francisco, San Francisco, CA, United States.;Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, United States. ^[2] UCSF CoLabs, University of California San Francisco, San Francisco, CA, United States.;ImmunoX Initiative, University of California San Francisco, San Francisco, CA, United States. ^[3] Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, United States. ^[4] Institute of Human Genetics, University of California San Francisco, San Francisco, CA, United States.;Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, United States. ^[5] Institute of Human Genetics, University of California San Francisco, San Francisco, CA, United States.;Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, United States.;Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, United States.;Parker Institute for Cancer Immunotherapy, San Francisco, CA, United States.;Chan Zuckerberg Biohub, San Francisco, CA, United States. ^[6] Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, United States.;Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States. ^[7]

关键词 autoimmune disease dermatomyositis immune phenotyping juvenile dermatomyositis (JDM)omics precision medicine single-cell sequencing

医学主题词 B-淋巴细胞(B-Lymphocytes);皮肌炎(Dermatomyositis);人类(Humans);白细胞, 单核(Leukocytes, Mononuclear);肌炎(Myositis);蛋白质组学(Proteomics)

DOI 10.3389/fimmu.2022.902232

PMID 35799782

发布时间 2024-09-27

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