Identification of a novel substrate motif of yeast separase and deciphering the recognition specificity using AlphaFold2 and molecular dynamics simulation.

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第一作者： Miaomiao,Liang

第一单位： School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: liangmiaomiao@sjtu.edu.cn.

作者： Miaomiao,Liang ^[1] ; Xu,Chen ^[2] ; Cheng,Zhu ^[3] ; Xiaoge,Liang ^[4] ; Zhuoqun,Gao ^[5] ; Shukun,Luo ^[6]

作者单位： School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: liangmiaomiao@sjtu.edu.cn. ^[1] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: cx199711@sjtu.edu.cn. ^[2] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: zhuchengshjd@sjtu.edu.cn. ^[3] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: liangxiaoge@sjtu.edu.cn. ^[4] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: gzq1999@sjtu.edu.cn. ^[5] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, PR China. Electronic address: shukunluo@sjtu.edu.cn. ^[6]

关键词 Chromosome segregation Securin Separase Substrate recognition

主题词细胞周期蛋白质类(Cell Cycle Proteins);染色体分离(Chromosome Segregation);内肽酶类(Endopeptidases);分子动力学模拟(Molecular Dynamics Simulation);酿酒酵母菌(Saccharomyces cerevisiae);酵母菌目(Saccharomycetales)

DOI 10.1016/j.bbrc.2022.06.056

PMID 35803173

发布时间 2022-08-01

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