Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway.

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第一作者： Gui-Min,Xue

第一单位： College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: xueguimin123@126.com.

作者： Gui-Min,Xue ^[1] ; Chen-Guang,Zhao ^[2] ; Jin-Feng,Xue ^[2] ; Kun,Du ^[2] ; Jiang-Jing,Duan ^[2] ; Hao,Pan ^[2] ; Meng,Li ^[2] ; Hui,Chen ^[2] ; Yan-Jun,Sun ^[2] ; Wei-Sheng,Feng ^[2] ; Ting,Ma ^[3] ; Wen-Da,Zhang ^[4]

作者单位： College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: xueguimin123@126.com. ^[1] College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China. ^[2] School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China. ^[3] Department of Pharmacy, Henan Key Laboratory for Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, 450052, China. Electronic address: zhangwenda16@126.com. ^[4]

关键词 Achillea alpina L.Asteraceae Germacranolide-type sesquiterpenoid Glucose consumption Guaianolide-type sesquiterpenoid Insulin resistance