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Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment (The ATLANTIS trial): protocol for a randomised double-blind placebo-controlled trial in primary care.

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第一作者： Sarah L,Alderson

第一单位： School of Medicine, Leeds Institute of Health Sciences, University of Leeds, University of Leeds, Room 10.39, Worsley Building, Clarendon Way, Leeds, LS9 9LU, UK. s.l.alderson@leeds.ac.uk.

作者： Sarah L,Alderson ^[1] ; Alexandra,Wright-Hughes ^[2] ; Alexander C,Ford ^[3] ; Amanda,Farrin ^[2] ; Suzanne,Hartley ^[2] ; Catherine,Fernandez ^[2] ; Christopher,Taylor ^[2] ; Pei Loo,Ow ^[2] ; Emma,Teasdale ^[4] ; Daniel,Howdon ^[5] ; Elspeth,Guthrie ^[5] ; Robbie,Foy ^[5] ; Matthew J,Ridd ^[6] ; Felicity L,Bishop ^[4] ; Delia,Muir ^[2] ; Matthew,Chaddock ^[7] ; Amy,Herbert ^[6] ; Deborah,Cooper ^[5] ; Ruth,Gibbins ^[8] ; Sonia,Newman ^[8] ; Heather,Cook ^[9] ; Roberta,Longo ^[5] ; Hazel,Everitt ^[8]

作者单位： School of Medicine, Leeds Institute of Health Sciences, University of Leeds, University of Leeds, Room 10.39, Worsley Building, Clarendon Way, Leeds, LS9 9LU, UK. s.l.alderson@leeds.ac.uk. ^[1] Clinical Trial Research Unit, Leeds Institute of Clinical Trials Research, School of Medicine, University of Leeds, Leeds, UK. ^[2] Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK.;Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK. ^[3] Centre for Clinical and Community Applications of Health Psychology, School of Psychology, University of Southampton, Southampton, UK. ^[4] School of Medicine, Leeds Institute of Health Sciences, University of Leeds, University of Leeds, Room 10.39, Worsley Building, Clarendon Way, Leeds, LS9 9LU, UK. ^[5] Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. ^[6] Let's Cure IBS, Sheffield, UK. ^[7] Primary Care Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK. ^[8] Exeter Clinical Trials Unit, University of Exeter, Exeter, UK. ^[9]

关键词 Amitriptyline Double-blind Irritable bowel syndrome Placebo Primary care Randomised controlled trial