Hepatic Expression of the Na<sup>+</sup>-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

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作者： Roman,Tremmel ^[1] ; Anne T,Nies ^[2] ; Barbara A C,van Eijck ^[1] ; Niklas,Handin ^[2] ; Mathias,Haag ^[3] ; Stefan,Winter ^[1] ; Florian A,Büttner ^[2] ; Charlotte,Kölz ^[4] ; Franziska,Klein ^[1] ; Pascale,Mazzola ^[2] ; Ute,Hofmann ^[1] ; Kathrin,Klein ^[2] ; Per,Hoffmann ^[1] ; Markus M,Nöthen ^[2] ; Fabienne Z,Gaugaz ^[1] ; Per,Artursson ^[2] ; Matthias,Schwab ^[1] ; Elke,Schaeffeler ^[2]

作者单位： Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany. ^[1] University of Tuebingen, 72076 Tuebingen, Germany. ^[2] iFIT Cluster of Excellence (EXC2180) "Image Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076 Tuebingen, Germany. ^[3] Department of Pharmacy, Uppsala University, 75123 Uppsala, Sweden. ^[4] Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. ^[5] Division of Medical Genetics, Department of Biomedicine, University of Basel, 4001 Basel, Switzerland. ^[6] Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany. ^[7] Departments of Clinical Pharmacology, and of Pharmacy and Biochemistry, University of Tuebingen, 72076 Tuebingen, Germany. ^[8]

关键词 DNA methylation HBV/HDV infection NTCP SLC10A1 bulevirtide epigenetics genetic variants metabolomics remdesivir