Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.

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作者： Haarin,Chun ^[1] ; James H,Kurasawa ^[1] ; Philip,Olivares ^[1] ; Ekaterina S,Marakasova ^[1] ; Svetlana A,Shestopal ^[1] ; Gabriela U,Hassink ^[1] ; Elena,Karnaukhova ^[1] ; Mary,Migliorini ^[2] ; Juliet O,Obi ^[3] ; Ally K,Smith ^[3] ; Patrick L,Wintrode ^[3] ; Prasannavenkatesh,Durai ^[4] ; Keunwan,Park ^[4] ; Daniel,Deredge ^[3] ; Dudley K,Strickland ^[2] ; Andrey G,Sarafanov ^[1]

作者单位： Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ^[1] Center for Vascular and Inflammatory Diseases, Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA. ^[2] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. ^[3] Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea. ^[4]

关键词 LDL-receptor related protein-associated protein blood coagulation factor VIII hemophilia A low density lipoprotein receptor low density lipoprotein receptor-related protein 1