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The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation.

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第一作者： Tiziana,Ginex

第一单位： Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain.

作者： Tiziana,Ginex ^[1] ; Clara,Marco-Marín ^[2] ; Miłosz,Wieczór ^[3] ; Carlos P,Mata ^[4] ; James,Krieger ^[5] ; Paula,Ruiz-Rodriguez ^[6] ; Maria Luisa,López-Redondo ^[7] ; Clara,Francés-Gómez ^[6] ; Roberto,Melero ^[5] ; Carlos Óscar,Sánchez-Sorzano ^[5] ; Marta,Martínez ^[5] ; Nadine,Gougeard ^[2] ; Alicia,Forcada-Nadal ^[2] ; Sara,Zamora-Caballero ^[7] ; Roberto,Gozalbo-Rovira ^[7] ; Carla,Sanz-Frasquet ^[7] ; Rocío,Arranz ^[5] ; Jeronimo,Bravo ^[7] ; Vicente,Rubio ^[2] ; Alberto,Marina ^[2] ; IBV-Covid19-Pipeline ^[6] ; Ron,Geller ^[8] ; Iñaki,Comas ^[1] ; Carmen,Gil ^[6] ; Mireia,Coscolla ^[9] ; Modesto,Orozco ^[2] ; José Luis,Llácer ^[5] ; Jose-Maria,Carazo

作者单位： Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain. ^[1] Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.;Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain. ^[2] Molecular Modeling and Bioinformatics, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. ^[3] Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.;Centro Nacional de Microbiología (CNM-ISCIII), Instituto de Salud Carlos III, Madrid, Spain. ^[4] Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain. ^[5] I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain. ^[6] Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain. ^[7] Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.;Centro para Investigación Biomédica en Red sobre Epidemiología y Salud Pública (CIBERESP), Valencia, Spain. ^[8] Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain.;Department of Biochemistry and Biomedicine, University of Barcelona, Barcelona, Spain. ^[9]

医学主题词人类(Humans);突变(Mutation);肽基二肽酶A(Peptidyl-Dipeptidase A);蛋白质结合(Protein Binding);受体, 病毒(Receptors, Virus)

DOI 10.1371/journal.ppat.1010631

PMID 35816514

发布时间 2025-10-31

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